A New Particle Type in Certain Connective Tissue Extracts.

I Acknowledgment is due E. I. du Pont de Nemours & Co., Inc., for this sample and relevant data. 1 Heidelberger, M., and Avery, 0. T., J. Exptl. Med., 38, 73 (1923); 40,301 (1924). 2 Hotchkiss, R. D., and Goebel, W. F., J. Biol. Chem., 121, 195 (1937); Reeves, R. E., and Goebel, W. F., Ibid., 139, 511 (1941). 3 Haworth, N., Kent, P. W., and Stacey, M., J. Chem. Soc., 1948, 1220; the polysaccharide described Ibid., 1211, cannot contain amino sugar, since it has been obtained nitrogen-free. Heidelberger, M., and Menzel, A. E. O., J. Biol. Chem., 118, 79 (1937). 4 Reviewed in Heidelberger, M., Bact. Rev., 3, 49 (1939); Chem. Rev., 24, 323 (1939). 6 Heidelberger, M., and Kendall, F. E., J. Exptl. Med., 61, 563 (1935). 6 Heidelberger, M., Kabat, E. A., and Shrivastava, D. L., Ibid., 65, 487 (1937); Heidelberger, M., Kabat, E. A., and Mayer, M., Ibid., 75, 35 (1942). 7 Sugg, J. Y., and Hehre, E. J., J. Immunol., 43, 119 (1942); cf. also Zozaya, J., J. Exptl. Med., 55, 353 (1932). 8 Kabat, E. A., and Berg, D., J. Immunol., May, 1953. In this paper it is shown, among other things, that two synthetic polyglucoses partially precipitate antibodies formed in man after injection of dextran. In part, also, in Ann. N. Y. Acad. Sci., 55, 471 (1952). 9 Heidelberger, M., MacLeod, C. M., Markowitz, H., and Roe, A. S., J. Exptl. Med., 91, 341 (1950). 10 Heidelberger, M., and Kendall, F. E., Ibid., 53, 625 (1931). 11 Heidelberger, M., and Kendall, F. E., Ibid., 61, 559 (1935). 12 Markham, R., Biochem. J., 36, 790 (1943); cf. also Kabat, E. A., and Mayer, M. M., Experimental Immunochemistry, C. C Thomas, Springfield, Ill., 1948. 13 Pacsu, B., personal communication. 14 Stacey, M., Biochem. J., 53: Proc. Biochem. Soc., xiii (1953); Endeavour, 12, 38 (1953).